12/31/2023 0 Comments Usmle step 1 example questionsThe child’s prenatal and postnatal histories are otherwise unremarkable, and a review of systems and physical examination are normal. The mother first noticed this when throwing away old diapers, which she describes as having a black discoloration. Dietary supplementation with which of the following will decrease this patient’s risk of further thrombotic complications?Testing of the urine or serum of this infant will likely reveal an elevated level of which compound?A 4-week-old infant is brought to the pediatrician for discolored urine. A CT pulmonary angiogram reveals a pulmonary embolism, and he is started on anticoagulation. Physical examination is notable for a tall and thin build, long limbs, and downward dislocation of the lenses. In the emergency room, he is tachycardic and hypoxic. Which of the following is the most appropriate treatment for this boy’s symptoms?Dietary supplementation with which of the following will decrease this patient’s risk of further thrombotic complications?A 22-year-old man with a past medical history of seizure disorder and mild intellectual disability presents with unilateral right lower extremity swelling and shortness of breath. Laboratory evaluation reveals an absolute lymphocyte count of 21,000 lymphocytes/microL. His vital signs are normal and physical examination is unremarkable. His mother reports that he has not had any immunizations since 4 months of age. The coughing spells last for several minutes and are frequently associated with post-tussive emesis. He was seen by his pediatrician 5 weeks ago for low grade fever, cough and runny nose. What is the mechanism of this shift in nutrient metabolism?Which of the following is the most appropriate treatment for this boy’s symptoms?A 6-year-old boy is evaluated for a cough that has been present for the last 6 weeks. When transitioned to a lactose-rich environment, growth initially slows but resumes following a short delay. The bacteria grow at a constant rate in a glucose-rich environment. coli are observed in the setting of different nutrient environments. You can see all the Knowmedge USMLE Step 1 Practice Questions here.USMLE Step 1 Practice QuizWhat is the mechanism of this shift in nutrient metabolism?In a study of prokaryotic metabolism, growth rates of E. For this calculation, one does not need to know the volume of distribution for the drug. The dosing rate can be calculated by multiplying the clearance rate by the desired therapeutic plasma concentration. The maintenance dose of a drug is dependent upon the clearance rate. In the example in Item 48, the loading dose would be 35 L (volume of distribution) X 3.5 mg/L (therapeutic concentration) equal to 122.5 mg. If the volume of distribution is large, due for example to peripheral binding of the drug, then the volume of distribution is relatively high and the loading dose may be correspondingly high, requiring that the loading dose be administered more slowly to avoid toxicity. Loading doses can be given intravenously and because the plasma concentration is reached almost immediately, the clearance rate can be ignored. The loading dose is independent of the clearance rate. The loading dose of a drug is defined as the X the. To achieve a loading dose of a drug where the volume of distribution of the drug is 35 L and the clearance rate is 70 ml/min, and the desired dose is 3.5 mg/L, one should administer how many mg of drug initially? USMLE Step 1 Practice Question: Pharmacology
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